看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。- [: ?, G9 w. E7 ?. O7 H
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Z6 R z5 g C) G4 Y/ nCurrently available feasibility data for possible combination strategies.
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1 }' M! v. G. kCombination Feasibility according to preliminary data
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( _* {0 S, R! K8 ^Bevacizumab + sorafenib Yes, reduced dose L7 Y* e3 o+ d
Bevacizumab + sunitinib† No - O6 f8 S* I2 s. J# J
Bevacizumab + temsirolimus Yes
% r6 B. _- H" ]Bevacizumab + everolimus Yes + L: F+ h' Q5 x# z7 \/ r
Sorafenib + sunitinib ?
+ N0 C* J( m; E0 T8 f8 A! uSorafenib + temsirolimus Yes, reduced dose
2 o. e5 _. E' Q4 w) eSorafenib + everolimus Yes, reduced dose ! j+ T4 J6 E" Y7 C j- Y* m# b
Sunitinib + temsirolimus† No
- M& f& ~& \9 g( q; O+ X$ N$ H( oSunitinib + everolimus ? : o4 O! }% K4 a9 E" C, h, _9 l& a; W
Temsirolimus + everolimus ?
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†Led to US FDA warning.3 p8 k* B* Z2 R2 [- }) v& p0 }
?: As yet unattempted combination.8 T' @3 X' V" O: @3 z @
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