平安! 发表于 2011-11-9 19:57 # I6 C0 j* R# M$ i" h! V5 F9 r, e
Pazopanib (100 mg/kg/day free base equivalent)
% X. j4 x m+ x3 R1 {: W& c 这是个已经在美国上市的老药了,能下载到正式药物使用说明书英文版。* ]' {" _( K! V$ n' d
搜索了一下,原料一大堆。
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7 g+ I' Z2 k! Q4 `3 u0 H3 j对不起!100mg/kg是用于移植瘤的,我弄错了。; N, d2 k& c) E( O2 X$ u
% l$ s8 ^: R v: |* U$ f以下是正版说明书的推荐用量。2 ?! j3 s* P# Z. t7 T! Y# u G
& H, }- U5 G8 x* o6 B0 E--------------------- DOSAGE AND ADMINISTRATION ----------------
. M ]( b6 r! }$ G2 J3 c4 s* 800 mg orally once daily without food (at least 1 hour before or 2 hours after a meal). (2.1) ( f/ F0 R. s5 M1 y
* Baseline moderate hepatic impairment – 200 mg orally once daily. Not recommended in patients with severe hepatic impairment. (2.2) 7 h0 z8 u x9 t0 |1 @3 N* K( Q
---------------------DOSAGE FORMS AND STRENGTHS --------------
5 T2 F' V2 H' k# S3 ~# F200 mg tablets. (3) ) w* L4 P$ F/ C6 h, W) z" i
-------------------------------CONTRAINDICATIONS------------------------ |