发给老马备查:4 J+ o5 H8 {0 L! H1 n5 ?% s
滴水察海(69304838) 15:23:23
# I) }' t1 m1 l+ D: h" q& R! z4 P老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
; J) i/ q" L+ ]吉非替尼和S-1连用的依据
% Z( s9 C; v, \' b" o* @Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
' l7 r/ I5 s! V' [9 b! F* E是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达" M; n/ T( _1 J: R! r) }
这样是不是推理出,耐药后,可以用S-1和培美了?
: L, A; m4 \- g! G/ g结论:
) T2 I$ M$ f% N; p2 u1 w3 f# G如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |