发给老马备查:
# o! T( c2 E, ?% _6 i: R$ l7 }5 _滴水察海(69304838) 15:23:232 e' Q. x: ~( f7 G" L; Y
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱: H# B9 x. m+ M2 D0 ?0 D! W$ {4 B' w
吉非替尼和S-1连用的依据
' a0 [* C* k, B( ?# K! v7 zGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.3 F- ]+ [8 \$ S# X6 f) T
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
( Q# i/ r3 `6 ~) k' i6 g/ F, G这样是不是推理出,耐药后,可以用S-1和培美了?
2 m9 P6 h- L, S结论:
) a2 Y9 p/ H, o/ Q, B9 z* H& n$ I如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |