发给老马备查:
; A; p' e9 m! ~滴水察海(69304838) 15:23:23/ v6 ^+ z, [) i D7 h1 |9 w) l
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱5 W2 x7 i2 `: j
吉非替尼和S-1连用的依据9 u o4 C3 H1 q" a" ~7 }
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.: L4 Z. U$ J- d) P# N
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
' p. t3 E0 P" S5 M$ \这样是不是推理出,耐药后,可以用S-1和培美了?( k; X% p1 e" U/ t5 {+ J( T& f* ]& }
结论:7 H! ] i+ W( ?2 ]0 D$ g# A
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |