发给老马备查:: _+ f0 e" a% M% y. w) p/ S
滴水察海(69304838) 15:23:23
; } S; r7 ~+ |( z5 a老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱. Z" Q6 u! ^! O: [0 j$ h5 o
吉非替尼和S-1连用的依据
* t2 J5 {7 c8 n' }4 V m% GGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
+ h) v! ] e" e! Z) N' n/ a是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达8 o! ]% M% ~- N4 v/ s4 ]; \6 j
这样是不是推理出,耐药后,可以用S-1和培美了?# y8 V F, j/ a& @4 r
结论:
9 j6 v, R$ u i% ]如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |