发给老马备查:: f0 L+ X( Y8 `( x& R8 @) [2 W
滴水察海(69304838) 15:23:23
4 v; p0 v. j: ]2 Q老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱* K5 S; U; X2 w, Y% E' m8 o
吉非替尼和S-1连用的依据
$ e! r) \& ~) o( `Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
+ l2 G" M+ x" ?- e, e2 j" O是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
+ P7 w3 f, }! t这样是不是推理出,耐药后,可以用S-1和培美了?- \8 |& B5 n' |- D7 t- X
结论:
0 W K! h) M$ M* x! c如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |