关于PD1在胆管的使用，请bluest给个建议

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最近一直在关注PD1，也请教了香港的邵医生，确实胆管还没有人试用过，所以没有数据。我妈妈手术完一个月了，三十年前结石手术时就做了胆肠吻合，转移到吻合的肠，手术病理肝和淋巴都好的，但是肠壁那里切缘是阳性。这样是不是就算是姑息术了？先不管PD1能不能在我们身上起到效果，我是愿意去尝试这四个疗程的，但是现在有点担心，PD1用后原来的肿瘤可能会先变大，有效果的才会再变小，那么如果我妈妈这种情况会不会出现使用以后肠道那里肿瘤变大的可能呢，如果PD1在我妈身上没有效果，但是肠道那里肿瘤变大岂不是有梗阻的危险？不知道我的理解有没有错，也不知道有没有胆管的患者用过PD1了，请教bluest，有这种可能吗？要不要尝试用一下呢？

bluest · 发表于 2015-2-27 11:07:51

Interaction of B7-H1 on intrahepatic cholangiocarcinoma cells with PD-1 on tumor-infiltrating T cells as a mechanism of immune evasion.
Ye Y1, Zhou L, Xie X, Jiang G, Xie H, Zheng S.
Author information

1Key Lab of Combined Multi-organ Transplantation, Ministry of Public Health, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.

Abstract
BACKGROUND AND OBJECTIVES:

The B7-H1/PD-1 pathway has recently been found to contribute to immune evasion of cancer cells from host immune system. This study aimed to investigate the expression of B7-H1 and its receptor PD-1 and to explore their significance in the progression of intraheptic cholangiocarcinoma (ICC).
METHODS:

Thirty-one surgically resected ICC tissues and the corresponding cancer adjacent tissues were enrolled from 2006 to 2007. Immunohistochemical studies were performed with antibody of B7-H1, PD-1, CD8, and CD4. Apoptosis status of tumor-infiltrating lymphocytes (TILs) was detected by TUNEL assay.
RESULTS:

Expression of B7-H1 and PD-1 was found to be up-regulated in ICC tissues compared with the cancer adjacent tissues. Tumor-related B7-H1 expression was significantly correlated with both tumor differentiation and pTNM stage and was inversely correlated with CD8+ TILs but not CD4+ TILs. TILs in primary carcinoma showed a high level of apoptosis.
CONCLUSION:

B7-H1/PD-1 pathway may be linked to malignant potential of ICC and contribute to tumor immune evasion by promoting CD8+ TILs apoptosis. Thus, this pathway may indeed be a potential therapeutic target in the treatment of this disease.
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只搜到一个浙大医院做的非人体实验，对治疗没有参考价值。